环境因素引起的哺乳动物跨代DNA甲基化修饰现象

doi:10.11843/j.issn.0366-6964.2017.12.001

畜牧兽医学报 ›› 2017, Vol. 48 ›› Issue (12): 2225-2231.doi: 10.11843/j.issn.0366-6964.2017.12.001

环境因素引起的哺乳动物跨代DNA甲基化修饰现象

甘麦邻¹, 杨大洪², 谭娅^1,3, 杨琼⁴, 蒲红州⁵, 张顺华^1*, 朱砺^1*

1. 四川农业大学动物科技学院, 成都 611130;
2. 四川省雅安市名山区农业局, 雅安 625100;
3. 贵州省畜牧兽医研究所, 贵阳 550005;
4. 成都农业科技职业学院, 成都 611130;
5. 四川省南江县农业局, 巴中 635600

收稿日期:2017-04-10 出版日期:2017-12-23 发布日期:2017-12-23
通讯作者: 张顺华,博士,硕士生导师,主要从事猪遗传育种研究,E-mail:363445986@qq.com;朱砺,教授,博士生导师,主要从事猪遗传育种研究,E-mail:zhuli7508@163.com
作者简介:甘麦邻(1993-),男,新疆喀什人,硕士生,主要从事动物遗传育种与繁殖研究,E-mail:1660600546@qq.com
基金资助:
四川省科技支撑计划项目（16ZC2838；2016NZ0089）；四川省科技富民强县专项行动计划项目（2015NZ0013）；四川省教育厅科研项目（16ZB0038）

The Study of Influence of Environment on Transgenerational Inheritance of DNA Methylation in Mammals

GAN Mai-lin¹, YANG Da-hong², TAN Ya^1,3, YANG Qiong⁴, PU Hong-zhou⁵, ZHANG Shun-hua^1*, ZHU Li^1*

1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China;
2. Mingshan District Agricultural Bureau, Ya'an 625100, China;
3. Animal Husbandry and Veterinary Institute of Guizhou Province, Guiyang 550005, China;
4. Chengdu Agricultural College, Chengdu 611130, China;
5. Nanjiang County Agricultural Bureau, Bazhong 635600, China

Received:2017-04-10 Online:2017-12-23 Published:2017-12-23

摘要/Abstract

摘要：

经典遗传学认为生物的遗传信息是由基因决定的，DNA序列发生的改变可以传递给后代，而表观遗传修饰则由于细胞重编程作用不能被传递到后代。近年来的研究发现，一些环境因素引起的表观遗传修饰也可以传递给后代，而DNA甲基化是表观遗传修饰的主要机制之一，也是近年来研究跨代遗传的热点。本文对近年来环境因素在哺乳动物世代继承中的DNA甲基化修饰相关研究进行综述，为进一步研究跨代遗传中的表观遗传修饰机制提供参考。

Abstract:

Classical genetics suggests that the genetic information of the organism is determined by the genes, that is, only the change of DNA sequence can be inherited, but the epigenetic DNA modifications can't be inherited because of the cell reprograming. Recent studies have found that some of the epigenetic modification caused by environmental factors can also be passed to the offspring, and DNA methylation is one of the main mechanisms of epigenetic modification, which is a hot spot in the transgenerational inheritance field. Herein, we focus on the transgenerational inheritance of DNA methylation caused by environmental factors, which may provide some references for further study on transgenerational inheritance.

中图分类号:

Q343.245

甘麦邻, 杨大洪, 谭娅, 杨琼, 蒲红州, 张顺华, 朱砺. 环境因素引起的哺乳动物跨代DNA甲基化修饰现象[J]. 畜牧兽医学报, 2017, 48(12): 2225-2231.

GAN Mai-lin, YANG Da-hong, TAN Ya, YANG Qiong, PU Hong-zhou, ZHANG Shun-hua, ZHU Li. The Study of Influence of Environment on Transgenerational Inheritance of DNA Methylation in Mammals[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(12): 2225-2231.

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环境因素引起的哺乳动物跨代DNA甲基化修饰现象

The Study of Influence of Environment on Transgenerational Inheritance of DNA Methylation in Mammals

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